月刊,1956年创刊
主管:军事医学科学院
主办:军事医学科学院
主编:张学敏
编辑部主任:刘术
原刊名:军事医学科学院院刊
编辑出版:《军事医学》编辑部
ISSN 1674-9960
CN 11-5950/R
邮发代号:82-757

Latest issue

2025 Volume 49 Issue 2   Published: 25 February 2025
  
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    Original articles
  • Original articles
    GAO Xinlong, HE Ying, WU Wenhui, MIN Tianjiao, LIU Lina, JIANG Beier
    Abstract ( ) Download PDF ( )   Knowledge map   Save
    Objective To study the mechanism by which acoustic wave stimulation improves cognitive function in sleep-deprived mice. Methods (1) Thirty-six male C57BL/6 mice were randomly divided into three groups: the control group,model group and acoustic wave group (n=12 per group). A sleep deprivation model was established using the modified multiple platform method. After 21 days of sleep deprivation in a row,mice in the acoustic wave group were exposed to 30-minute acoustic wave stimulation at 40 dB. (2) During sleep deprivation, the health status of each group of mice was recorded, including the mental state and body weight. (3) After 21 days of sleep deprivation, behavioral tests (open field test, novel object recognition test, Y-maze and Morris water maze) were performed to assess the spontaneous activity, spatial exploration, and such cognitive functions as learning and memory in mice. Immunohistochemistry was conducted to analyze the expressions of neuronal nuclear antigen (NeuN), glial fibrillary acidic protein (GFAP) and ionized calcium-binding adaptor molecule 1 (Iba-1)in the hippocampus. Quantitative real-time PCR (qPCR) was used to measure the expression levels of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α) and inducible nitric oxide synthase (iNOS) in the hippocampus. (4) Transcriptome sequencing was employed to explore the mechanism underlying the improvement of cognitive impairment by acoustic wave stimulation. Results After 21 days of sleep deprivation, acoustic wave stimulation significantly alleviated weight loss in mice (P<0.01). The accuracy of Y-maze spontaneous alternation, indexes of novel object discrimination, the time spent in the target quadrant and the number of times the mice crossed the platformin the Morris water maze were all significantly increased (P<0.05), while the escape latency was significantly reduced (P<0.05). The average optical density of NeuN in the hippocampal CA3 region significantly increased (P<0.05), GFAP and Iba-1 immunopositive cell counts significantly decreased (P<0.01), and the mRNA levels of IL-6, TNF-α, and iNOS in the hippocampal tissue were significantly reduced (P<0.05). Conclusion Acoustic wave stimulation can repair neural damage, modulate hippocampal inflammatory responses, and improve cognitive deficits induced by sleep deprivation.
  • Original articles
    YUE Liangchen, RONG Zhen
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    Objective To develop a deep learning algorithm(Bio-section to Gene, B2G) for predicting spatially resolved gene expression profiles directly from histopathological images. Methods Digital histopathological images were processed through an integrated framework comprising convolutional neural networks (CNNs) and the Transformer architecture. Local histological features were extracted by the CNN module while global feature correlations were captured by the Transformer module. Cellular characteristics in digital tissue sections were systematically identified, followed by regression-based prediction of spatially resolved gene expression profiles. Results The B2G algorithm demonstrated significantly higher prediction accuracy than existing methods (weighted median PCC 0.1776). This framework exhibited robust performance across multiple cancer types and histological preparation protocols. Conclusion This computational approach may provide a morphology-driven strategy for spatial transcriptomic analysis. The framework could facilitate cost-effective biomarker discovery in clinical specimens while reducing reliance on specialized molecular techniques. Additionally, it might enable further exploration of tumor microenvironment heterogeneity.
  • Original articles
    HU Xiao, GAO Yanlin, SHI Yunping, LIU Yang, WANG Chao, ZHOU Ying, LI Wei, LI Jiaze, LI Gang
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    Objective To analyze the epidemiology and trends of measles,tuberculosis,pertussis,scarlet fever,influenza,mumps and rubella in Beijing between 2014 and 2023 in order to provide data for prevention and control of related diseases. Methods Data on the incidences of seven respiratory infectious diseases in Beijing between 2014 and 2023 was collected. Descriptive epidemiological methods were employed to analyze their demographic,temporal and spatial distribution. Joinpoint regression analysis was used to assess temporal trends in incidence. Results A total of 1 406 777 cases of seven respiratory infectious diseases were reported in Beijing between 2014 and 2023,which corresponded to an average crude rate of 649.76/100 000 reported annually. The crude rate of incidencewas higher among females than among males,with the most vulnerable age groups being 0-4 years and 5-19 years,and was higher in the six districts than on the outskirts.Most of the respiratory infectious diseases peaked in winter and spring. The annual increase in the incidence of respiratory infectious diseases in Beijing in this period averaged 27.27%,with no statistically significant differences in trends. The incidence rates of measles,tuberculosis,scarlet fever,mumps and rubella decreased significantly while those of pertussis and influenza increased,but with no statistically significant difference. Conclusion The overall incidence of major respiratory infectious diseases in Beijing is increasing. It is recommended that more people get vaccinated,surveillance of such diseases as pertussis and influenza be enhanced,and regional health resources be allocated more effectively,all of which will be critical to subsequent prevention and control of respiratory infectious diseases in Beijing.
  • Original articles
    WANG Bin, PANG Shuai, LÜ Shuili, CHANG Kuaile
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    Objective To study the effects of Shugan Jieyu capsules on the cardiac function and state of mind of chronic heart failure(CHF) patients with anxiety and depression. Methods Ninety-four CHF patients with anxiety and depression were randomly divided into the Shugan Jieyu capsule treatment group and mental therapy control group. Self-rating depression Scale(SDS), self-rating anxiety scale(SAS), left ventricular ejection fraction (LVEF), N-terminal pro-B-type natriuretic peptide(NT-proBNP), the 6-minute walking test(6MWT), hemoglobin(Hb), interleukin-6(IL-6), albumin(ALB) and high-sensitivity c-reactive protein(hs-CRP) were compared between the two groups before and after treatment using t-tests and chi-square tests in order to find out about the efficacy of Shugan Jieyu capsules in CHF patients with anxiety and depression. Results After 8 weeks of treatment, SDS, SAS, NT-proBNP, hs-CRP and IL-6 were all significantly lower, especially in the treatment group, while LVEF, 6MWT,Hb and ALB were significantly higher or longer, particularly in the treatment group. Conclusion Shugan Jieyu capsules can effectively alleviate anxiety and depression in CHF patients, improve the cardiac function and nutritional status, and mitigate inflammation.
  • Original articles
    LIU Anheng, GUO Qing, BAI Xupeng, LI Lijun, LUO Jianping
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    Objective To study the risk factors for in-hospital mortality in patients with acute myocardial infarction (AMI) undergoing emergency percutaneous coronary intervention (EPCI). Methods Nine hundred and eight patients with acute myocardial infarction (AMI) who underwent EPCI at Beijing Jingmei Group General Hospital between September 2016 and December 2022 were enrolled and divided into an in-hospital death group (36 cases) and a survival group (872 cases) based on in-hospital outcomes. The basic information, clinical indicators, results of coronary angiography, outcomes of EPCI, and complications were compared between the two groups. Multiple logistic regression analysis was conducted to identify the risk factors for in-hospital mortality during EPCI. Results The age and serum creatinine levels of the death group were higher than those of the survival group (P<0.05), and the estimated glomerular filtration rate (eGFR) and hemoglobin (Hb) levels were lower than those of the survival group (P<0.05). The proportion of diabetes mellitus, cerebral infarction, cardiogenic shock, left main culprit lesion, rapid ventricular arrhythmia, TIMI flow grade <3 after EPCI for culprit vessel, and intra-aortic balloon pump (IABP) implantation in the death group were higher than those of the survival group (P<0.05). The results of multiple logistic regression analysis showed that age, cardiogenic shock, TIMI flow grade <3 after culprit vessel intervention, and rapid ventricular arrhythmia had a statistically significant impact on in-hospital mortality in EPCI (P<0.05). Conclusion Age, cardiogenic shock, TIMI flow grade <3 after PCI for culprit vessels, and rapid ventricular arrhythmia are independent risk factors for in-hospital mortality in EPCI patients with AMI.
  • Original articles
    ZHANG Chao, CHEN Kai, LIU Panpan, YANG Xinjun
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    The special natural environment of the plateau brings about great difficulties and challenges to the field medical support. The serious injury treatment group of the field medical team is responsible for the early treatment of the critically injured, which is highly demanding and is more likely to be adversely affected by the plateau environment. Based on the real experiences and current reality, this paper outlines the priorities of work done by the serious injury treatment group on the plateau in terms of personnel selection, professional training, material preparation, site construction, treatment regimens and combat readiness in the hope of providing references for the medical support for China′s the military on the plateau.
  • Original articles
    WANG Wenxiao, WANG Xinzhe, LI Qiu, WANG Junqiao
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    Acceptance commitment therapy is accepted as a new psychological therapy to provide psychological treatment and rehabilitation for soldiers, to ensure their health level and maintain the combat effectiveness of the army. In this paper, the applications of acceptance commitment therapy in military personnel are reviewed, including improving post-traumatic stress disorders, relieving postoperative or chronic pain, mitigating anxiety and depression, controlling weight, quitting smoking, and controlling alcohol use disorders. Acceptance commitment therapy is highly applicable among soldiers, especially veterans, exceedingly effective among female soldiers with post-traumatic stress disorders and better than other traditional therapies in treating post-traumatic stress disorders combined with substance use disorders or combined with chronic pain. However, traditional therapy is more effective than acceptance commitment therapy in improving sleep. Unfortunately, the number of current studies is small, research is not widely-distributed geographically, and domestic studies are lacking. Multi-center randomized controlled studies with large samples on the basis of foreign studies are needed to verify the applicability of acceptance commitment therapy in Chinese military.
  • Original articles
    LIU Mai, ZHANG Yin
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    In 2023, the U.S. Defense Advanced Research Projects Agency (DARPA) continued to advance the deployment of biotechnology projects. By translating cutting-edge biotechnological breakthroughs into practical applications, DARPA provided new methods to enhance the U.S. military capabilities in treating war wounds, improving the performance of facilities and equipment, and boosting soldier effectiveness. This paper offers an in-depth analysis of the progress of DARPA biotechnology projects in 2023, aiming to provide reference for related research endeavors in China.
  • Reviews
  • Reviews
    ZHANG Cheng, YU Ningkang, ZHAO Chen, WANG Jingfeng, SHEN Zhiqiang
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    Cell-free biosensors are detection tools that involve cell-free protein synthesis and consist of recognition elements and reporting elements. These biosensors offer several advantages, such as the ease of construction, a significant specificity and a high sensitivity. By overcoming the limitations associated with cell survival and cell membrane barriers, cell-free biosensors can considerably reduce response times. This article reviewed the recognition and reporting components of cell-free biosensors, summarizes recent research advancements in their applications to such spheres of public health as environmental monitoring and disease diagnosis, and explores the programmability and logical analysis capabilities of these biosensors. Future developments in this field are also predicted.
  • Reviews
    YU Ying, ZHANG Liqing, WANG Lijuan, QI Fengxue
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    Neuroimaging techniques are tools used to investigate and monitor the activity of the nervous system. This study reviews studies that have attempted to quantify athletes′ brain using neuroimaging techniques, and summarizes the specific changes in athletes′ brain as evidenced by structural magnetic resonance imaging, functional magnetic resonance imaging, functional near-infrared spectroscopy, transcranial magnetic stimulation and electroencephalography. Open-skill sports have been found to increase the brain volume and resting-state functional connectivity related to athletes′ executive control, somatosensory processing, vision, and balance coordination, whereas closed-skill sports may decrease the brain volume and resting-state functional connectivity related to athletes′ episodic memory, emotional processing and executive functions. Brain regions associated with executive functions, body awareness, motor learning, and episodic memory exhibit stronger activation during tasks. Athletes demonstrate higher neural excitability and neural efficiency. The association between sports training and the brain should be explored through multimodal neuroimaging techniques, which will play a significant role in athlete selection, real-time status monitoring and long-term training supervision.
  • Reviews
    TAN Jiyuan, GAO Yan, LI Jingchao, YIN Yue, LUO Wenzhe, WANG Yan
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    Pyruvate kinase M2 (PKM2) is closely linked to a variety of neurological disorders, involved in the onset and progression of a wide range of diseases, including Alzheimer′s disease, Parkinson′s disease, multiple sclerosis and traumatic brain injury through such mechanisms as aerobic glycolysis, oxidative stress, inflammation and apoptosis.This review is intended to provide an overview of the biological characteristics of PKM2 and its role in the pathophysiological mechanisms of neurological disorders. A better understanding of the correlations between PKM2 and the development of neurological diseases can offer new insights into and references for the clinical diagnosis and treatment of these conditions.
  • Short report
  • Short report
    ZHANG Hui, ZHANG Wenbo, LIANG Wenqi, HUO Yanhong
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