articles
高哲
2015, 39(10): 0-0.
[摘要] 目的 通过给予糖耐量正常受试者不同类型脂肪酸饮食，探讨其对肠促胰岛素、胰岛β细胞功能的影响。方法 健康受试者经标准饮食洗脱1周后，随机接受高饱和脂肪酸饮食、高不饱和脂肪酸饮食作为早餐摄入，每组饮食间隔期采用标准饮食洗脱1周。分别测定进餐后0分钟、30分钟、60分钟、120分钟、180分钟、240分钟血糖、血脂、游离脂肪酸、胰岛素、抑胃多肽（gastric inhibitory polypeptide, GIP)和胰高血糖素样肽-1 (glucagon-like peptide-1,GLP-1)水平。评估不同类型脂肪酸对肠促胰岛素、胰岛β细胞功能的影响。结果 1.曲线下面积分析。进餐后HSF组、HMF组血糖水平无明显改变，两组间无统计学差异（P>0.05）。HSF组与HMF组相比AUCins240min增高，差异有统计学意义（P<0.05）。HSF组与HMF组相比AUCTG30min及AUCTG240min均增高，差异有统计学意义（P<0.05）。HSF组与HMF组相比AUCFFA240min增高，差异有统计学意义（P<0.05）。进餐后HSF组与HMF组相比AUCGIP30min、AUCGIP240min均减低，差异有统计学意义（P<0.05）。HSF组与HMF组相比AUCGLP-1 30min、 AUCGLP-1 240min均减低，差异有统计学意义（P<0.05）。胰岛β细胞功能指数分析。两组间ΔI30/ΔG30无统计学差异（P>0.05）。HSF组与HMF组相比AUCI/AUCG增高，差异有统计学意义（P<0.05）。结论 1. 不同类型脂肪酸饮食可影响GIP、GLP-1分泌及胰岛功能变化。2.高不饱和脂肪酸饮食促进GIP、GLP-1分泌作用最明显，但高饱和脂肪酸饮食可促进更多胰岛素的分泌，胰岛β细胞功能指数也明显增高。
[关键词]胰高血糖素样肽-1；抑胃多肽；饱和脂肪酸；不饱和脂肪酸
Effects of dietary fat acids on incretin and islet function
Gao Zhe, Yan Xiaolu, Song Guangyao, Ma Huijuan, Dong Chunxia
[ABSTRACT] Objective To explore the effect of dietary fat acids on incretin and islet function in healthy adults. Methods Before each test, healthy subjects received a 1-week pre-experiment eucaloric diet. In a randomized order each subjects consumed the two meals containing different fat acids, including high saturated fat acid (HSF) and high monounsaturated fat acid (HMF), on two separate occasions with a minimum 1-week washout among meals. At 0,30,60,120,180 and 240 minute following meal intake, plasma concentrations of gastric inhibitory polypeptide(GIP), glucagon-like peptide-1(GLP-1) and serum concentrations of glucose, insulin, triglyceride(TG) and free fatty acid (FFA) were measured. Results Analysis of the areas under the curve of glucose, inslulin, TG, FFA, GIP and GLP-1. Postprandia glucose did not increase significantly following HSF and HMF meals (P>0.05). Comparing with HMF meal, significant increase in AUCins240min was observed following HSF meal (P<0.05). AUCTG30min and AUCTG240min were significantly higher following HSF meal as compared with HMF meal (P<0.05). And AUCFFA240min was significantly higher following HSF meal as compared with HMF meal (P<0.05). Compared with HMF meal,a significant decrease in AUCGIP30min and AUCGIP240min was found following HSF meal (P<0.05). Compared with HMF meal, significant decrease in AUCGLP-1 30min and AUCGLP-1 240min was found following HSF meal (P<0.05). 2.Additionally,the empirical indexes of postprandial βcell function were assessed. No significant difference was observed inΔI30/ΔG30 following HSF and HMF meals (P>0.05). AUCI/AUCG was significantly lower following HMF meal as compared with HSF meal (P<0.05). Conclusion 1.In conclusion, this study demonstrates that circulating GIP,GLP-1 andβcell function are affected by the dietary fat acids in healthy adults.2.HMF meal may stimulate GIP and GLP-1 secretion to a higher extent than HSF meal.But HSF meal promotes postprandial elevations in insulin and indexes of postprandial βcell function.
[Key words] glucagon-like peptide-1, gastric inhibitory polypeptide, saturated fat acid, monounsaturated fat aci
